System Security in an Open Lab Environment

This thesis presents a system security process for computer workstations in a university open lab environment, which was developed and implemented for the Lumpkin Hall Computer Labs at Eastern Illinois University (EIU). The system security includes the use of policies and NTFS permissions, registry hacks and script files. These techniques were applied to a mixture of Windows NT 4.0 service pack 6a and Windows 2000 Professional workstations in the Lumpkin Hall Computer Labs. They were then tested for appropriate security setup using a Network Security Checksheet and a survey. The Network Security Checksheet ensured that all of the workstations were configured properly and that the security settings where working properly to protect against known Windows exploits. A survey was used to validate the accessibility to the workstations for students in the School of Business at EIU. This new system security setup has decreased the maintenance workload by approximately 25%

Applied Calibration and Validation Method of Dynamic Process Simulation for Crushing Plants

There is a need within the production industry for digitalization and the development of meaningful functionality for production operation. One such industry is aggregate production, characterized by continuous production operation, where the digital transformation can bring operational adaptability to customer demand. Dynamic process simulations have the ability to capture the change in production performance of aggregate production over time. However, there is a need to develop cost-efficient methodologies to integrate calibrations and validation of models. This paper presents a method of integrating an experimental and data-driven approach for calibration and validation for crushing plant equipment and a process model. The method uses an error minimization optimization formulation to calibrate the equipment models, followed by the validation of the process model. The paper discusses various details such as experimental calibration procedure, applied error functions, optimization problem formulation, and the future development needed to completely realize the procedure for industrial use. The validated simulation model can be used for performing process planning and process optimization activities for the crushing plant’s operation

Half a century of amyloids: past, present and future

Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science and engineering, the cross-ß architecture has been a constant thread underlying the structural characteristics of pathological and functional amyloids, and realizing that amyloid structures can be both pathological and functional in nature has fuelled innovations in artificial amyloids, whose use today ranges from water purification to 3D printing. At the conclusion of a half century since Eanes and Glenner's seminal study of amyloids in humans, this review commemorates the occasion by documenting the major milestones in amyloid research to date, from the perspectives of structural biology, biophysics, medicine, microbiology, engineering and nanotechnology. We also discuss new challenges and opportunities to drive this interdisciplinary field moving forward. This journal i

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Instrumentvård och ergonomi ­ en bristvara inom elgitarrpedagogiken?

     Efter att aktivt ha musicerat i drygt femton år, främst som elgitarrist, slog det mig att jag aldrig sett något läromedel för elgitarr som tar upp ämnena instrumentvård och ergonomi. Efter många samtal med medstudenter och musiker kom jag fram till att det inte bara var jag som upptäckt detta, utan att många hade samma erfarenhet och funderat i samma banor. Syftet är att undersöka hur ämnena ergonomi och instrumentvård behandlas i läromedel för elgitarr och om det finns ett behov för ett specialiserat läromedel som behandlar dessa ämnen mer ingående.  Frågeställningarna för arbetet var: Tas ämnena instrumentvård och ergonomi upp tillräckligt ofta och ingående i befintligt undervisningsmaterial för elgitarr, finns det intresse bland lärare för ett undervisningsmaterial som behandlade dessa ämnen mer ingående, finns det ett behov av ett sådant studiematerial, och vad behövs för att sammanställa ett sådant studiematerial? Metoderna jag använt mig av är  litteraturstudier av 4 läroböcker för elgitarr, kvalitativ studie av Stojan Kaladjevs doktorsavhandling Ergonomi i musikundervisningen – kognitiva och ergonomiska aspekter på instrumentalspel, ostrukturerat frågeformulär till tio aktiva lärare i  elgitarr, samt en studie av informationsutbudet för instrumentvård för elgitarr på internet. Jag fick fram ett tydligt resultat. I 4 läroböcker för elgitarr representerades ämnet ergonomi med fyra meningar och en bild, instrumentvård inte alls. Enkätundersökningen pekar emot att en stor del av elgitarrlärarna själva fått bristande utbildning i dessa ämnen, anser att ett läromedel behövs, och är personligen intresserade av ett sådant. Med stöd av Stojan Kaladjevs avhandling och mina empiriska studier är min slutsats att behovet av ett specialiserat undervisningsmaterial finns, att dessa ämnen är en bristvara inom elgitarrlitteraturen, att många lärare och elever skulle ha nytta av ett sådant, och att stora delar av kunskaperna som behövs fö

System Security in an Open Lab Environment

This thesis presents a system security process for computer workstations in a university open lab environment, which was developed and implemented for the Lumpkin Hall Computer Labs at Eastern Illinois University (EIU). The system security includes the use of policies and NTFS permissions, registry hacks and script files. These techniques were applied to a mixture of Windows NT 4.0 service pack 6a and Windows 2000 Professional workstations in the Lumpkin Hall Computer Labs. They were then tested for appropriate security setup using a Network Security Checksheet and a survey. The Network Security Checksheet ensured that all of the workstations were configured properly and that the security settings where working properly to protect against known Windows exploits. A survey was used to validate the accessibility to the workstations for students in the School of Business at EIU. This new system security setup has decreased the maintenance workload by approximately 25%

Investigation of High Speed Cone Crushing Using Laboratory Scale Experiments and DEM

Cone crushers are commonly used in secondary and tertiary crushing stages in comminution circuits. A multitudeof factors and variables influence the performance in terms of throughput capacity, size reduction, power draw and wear.Crushers are normally installed and operated at a fixed eccentric speed setting. By installing variable frequency drives and realtimeoptimization algorithms Hulth\ue9n and Evertsson have shown that the eccentric speed can be used as a variable to optimizethe yield and improve the performance. However, the influence of eccentric speeds above the normal operational range hasbeen scarcely reported on in the literature.This paper aims at reporting on the result from an exploratory study where experiments and simulations have been used toevaluate cone crusher operation at high eccentric speed levels ranging from 10-40 Hz. A laboratory Morg\ue5rdshammar conecrusher has been refurbished for the purpose of the study. A preliminary set of experiments have been performed where resultsshowed that the chamber geometry has a vital importance. The same behaviour as observed in the experiments was also furtherunderstood by using DEM simulations leading to the design of a new chamber geometry.The new chamber design have been evaluated using DEM at four eccentric speeds and two different close side settings. Therock model has been calibrated by single particle breakage experiments and is based on the bonded particle model. The productparticle size distribution has been estimated by image analysis of the bonded cluster discharge. The work addresses and showsresults relevant to three areas in comminution and engineering research; Simulation driven design, DEM modelling, Conecrusher theory

Cone crusher performance evaluation using DEM simulations and laboratory experiments for model validation

Cone crushers are commonly used for secondary and tertiary crushing stages in the aggregate and mining industry. It has previously been demonstrated that the discrete element method (DEM) can be used to simulate rock breakage in crushers using a variety of modelling techniques. In order to provide confidence in the simulation results the DEM models need to be validated against experimental data. Such validation efforts are scarcely reported in the existing literature and there are no standardized procedures defined. In this paper a laboratory cone crusher is simulated using DEM and the results are compared with laboratory experiments. The rock material is modelled using the Bonded Particle Model approach calibrated against single particle breakage experiments. Two case simulations have been performed investigating the influence of eccentric speed. The laboratory crusher is a Morg\ue5rdshammar B90 cone crusher that has been equipped with custom machined liners, variable speed drive and a National Instruments data acquisition system. The results provide novel insight regarding the stochastic flow behaviour of particles when exited by the mantle at high frequency. The estimated product size distribution matches the experimental results relatively well when evaluating the corresponding coarse region that is feasible to calculate from the DEM product discharge data

Control systems for improvement of cone crusher yield and operation

Gyratory and cone crushers are regaining interest and are becoming more frequently used in order to create more energy efficient comminution circuits. A typical example is found in coarse comminution circuits were HPGRs are used as a first milling stage. In this case the preparation of a suitable feed with a well-defined width of the particle size distribution and a controlled top size are of high importance. In turn, this emphasizes the importance of a stable and controlled operation of the preceding crushing stages. Control systems for cone and gyratory crushers were first introduced during the early 60ths. The common opinion is that if these systems are able to compensate for the wear of the crushing liners the production yield can be increased with 20-25%. Over the years these types of systems have been widely used but the theory behind the principles have not been thoroughly scientifically scrutinized and presented. Of special interest is the capability to protect the crushers from long term overloading commonly defined as fatigue.With developments in electronics and plant control the crusher control systems have become more refined over the years. Though, there are sometimes conflicting interests in the control strategies between process requirements and crusher protection. In the paper an overview of the challenges, opportunities and existing control systems for cone and gyratory crushers is presented. A requirement specification for a system that is possible to fully integrate into modern plant control systems is outlined

Control Systems for Improvement of Cone Crusher Production Yield and Fatigue Life

Control systems for cone and gyratory crushers were first introduced during the early 60ths. The common opinion is that if these systems are able to compensate for the wear of the crushing liners the production yield can be increased with 20-25%. Over the years these types of systems have been widely used but the theory behind the principles have not been thoroughly scientifically scrutinized and presented. Of special interest is the capability to protect the crushers from long term overloading commonly defined as fatigue